Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults

HA Vanderven; I Barr; A Reynaldi; AK Wheatley; BD Wines; MP Davenport; PM Hogarth; SJ Kent

Journal article

Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults

HA Vanderven, I Barr, A Reynaldi, AK Wheatley, BD Wines, MP Davenport, PM Hogarth, SJ Kent

Vaccine | ELSEVIER SCI LTD | Published : 2020

DOI: 10.1016/j.vaccine.2020.01.066

Abstract

Background: Seasonal influenza vaccination with a standard trivalent influenza vaccine (TIV) induces a modest, and cross-reactive, Fc functional antibody response in older adults. Recent improvements to influenza vaccines include a quadrivalent influenza vaccine (QIV) and a TIV adjuvanted with the squalene-based oil-in-water emulsion MF59. Methods: Pre- and post-vaccination serum samples from older adults vaccinated with QIV (n = 27) and adjuvanted TIV (n = 44) were studied using hemagglutination inhibition (HAI) assays and dimeric Fc-gamma receptor IIIa binding ELISAs, as a surrogate of antibody-dependent cellular cytotoxicity (ADCC). Results: We found that the unadjuvanted QIV elicited a s..

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University of Melbourne Researchers

Ian Barr Author

Adam Wheatley Author

P. Mark Hogarth Author

Stephen Kent Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (award number 1052979 to SJ.K.) and James Cook University (laboratory start-up funding to H.A.V.). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.